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| Tohru Ikuta | |
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Office Phone: (706) 721-3098 Office Address: CB 2803 E-mail: TIKUTA@mail.mcg.edu Appointment Date: March 2004 Appointment Type: Full-Time |
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| Academic Rank(s) | |||
| Rank | Department | Section | School |
| Associate Professor | Graduate Studies | Graduate Studies | |
| Associate Professor | Anesthesiology and Perioperative Medicine | Medicine | |
| Education |
| MD; 1977; Kyushu University |
| PHD; 1987; Kyushu University |
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Teaching Areas * Hematological disorders such as sickle cell disease and thalassemias; * Intracellular signaling pathways in hematopoietic stem cells; * Transcriptional and translational regulation of gene expression in hematopoietic cells * Molecular actions of growth factors and cytokines Research Areas Our laboratory has been working on mechanisms responsible for gene expression in erythroid-lineage cells. We have currently been focusing on the following three projects. First project is to study the molecular mechanism by which expression of the human beta-like globin genes is regulated during development, where we will characterize cis-acting elements as well as transcription factors. Second project focuses on identifying intracellular signaling pathways that are involved in the regulation of fetal globin gene expression; recently, we are studying the roles of cyclic nucleotides. Third project is to develop new therapeutics for anemic disorders such as sickle cell disease and beta-thalassemia; specifically, we are interested in the roles of phosphodiesterases in regulating expression of beta-like globin genes. Clinical Interests Anemic disorders such as sickle cell disease and thalassemias Molecular basis of leukemia Gene therapy for hematological disorders |
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