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Jack C. Yu
Office Phone: (706) 721-6864
Office Address: HB 5047
E-mail: JYU@mail.mcg.edu

Appointment Date: July 1994
Appointment Type: Full-Time

Title(s)
Title/Rank Department/Division Section School/Unit
Section Chief Surgery Plastic Surgery Medicine
Hatcher Chair in Surgery Surgery Medicine

Academic Rank(s)
Rank Department Section School
Professor Surgery Plastic Surgery Medicine
Assistant Professor Pediatrics Medicine

Education
MD; 1985; University of Pennsylvania
MS; 1984; University of Pennsylvania
DMD; 1982; University of Pennsylvania

Teaching Areas
The education of plastic surgery residents is my primary duty as a teacher. I am also very interested in the design and execution of courses in medical student education. I participated in Problem Based Learning whenever my schedule allowed. Introduction to Plastic Surgery is a minicourse for the first year medical students during the first part of their second semester. Clinical education, especially the acquisition of surgical skills, is a balance between student's needs to practice and the patients well being. It is on the shoulder of the academic surgeons that both are maximized.

Research Areas
My main research focus is to develop a massive parallel array consisting of very high order Markov processes to explain why form follows function in the morphogenesis of the mammalian cranium. Rules based on clinical observations, experiments and classical mechanics are placed into an algorithm which when repeatedly iterated will generate complex adaptive behavior typically associated with osseous tissue. The core elements are as follows: Stress causes bone strain, bone strain causes osteocytic strain which lead to increase in osteocyte plasma membrane permeability in some cells (following a Gaussian distribution) This permeability increase leads to diffusion of FGF-2 into ECM. FGF-2 binds with FGF-2 R and initiate down stream effects eventually resulting in nuclear translocation of key factors which modify histones and allow transcription. This lead to mitosis and increase in osteoprogenitors . More matrix is produced, the local regional unit cross sectional area, A, is increased and the stress, F/A therefore is restored. This repeated iteration function should in theory yield anisotropic , trabeculae-like, "bone" with the internal mesoarchitecture in alignment with principle stress lines. These earlier works have resulted in my current interest and focus on cyclic stimulation of the musculo-skeletal system to prevent age-related bone and muscle loss.

Clinical Interests
Surgical and non-surgical correction of congenital and acquired deformities of the craniofacial structures are my main areas of clinical interests. We perform fronto-orbital advancements, total calvarial vault reshaping, post-traumatic orbitofacial reconstruction, and distraction osteogenesis of both the maxilla and mandible. We also have a well-staffed cleft lip and cleft palate team (which together with the craniofacial team make up the MCG Craniofacial Center). Our teamm orthodontist uses the latest methods called naso-alveoalr molding, or NAM, in optimizing the outcome of surgical repair. I also perform more traditional aesthetic surgeries such as facelift, blepharoplasties, lip augmentations, and rhinoplasties.

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